We use Drosophila as a model to study the nervous system. In the Davis lab we study how post-transcriptional regulation of RNA is involved in brain development, stem-cell biology and synaptic plasticity.
We use our expertise in RNA biology to better understand how RNA plays a role in virus biology and infection dynamics. We study a range of viruses, including Sars Cov2, HIV, Sindbis and others.
Our multi-disciplinary team work to develop new microscope hardware and associated software to study biological questions in new ways. This ranges from new cutting-edge super-resolution microscopes, 3D-printed microscopes for outreach and bespoke machines to software solutions used to handle and interpret large imaging datasets
For anyone interested in our work who doesn't have a science background we explain what we do in straightforward, non-technical language. Whether you're an adult who hasn't done science since school, or a school student who wants to learn more we have accessible information for you here.
We use the Drosophila neuromuscular junction as a model to study the role RNA and post-transcriptional regulation play in synaptic growth and plasticity.
How do you build a brain? We investigate this question by researching the part RNA has to play in regulating growth, division and differentiation of Drosophila neuroblasts.
A large-scale project where we have used single-molecule FISH to find the protein and mRNA of hundreds of genes throughout the fly nervous system
Our large datasets generated by imaging and molecular genetics projects require specialist software for storage, curation and analysis. We develop in-house software and adapt existing programmes to help us approach these challenging tasks.
In response to the global pandemic, we have teamed up with our virology collaborators to apply out cutting edge RNA and imaging methods to study the Sars Cov2 virus
We apply our cutting-edge imaging and RNA-biology techniques to help understand how viral infection progresses in mammalian cells.
RNA is the central focus of much of the research in the Davis Lab. We use and develop methods to study post-transcriptional regulation of RNA
In order to push the boundaries of imaging data, we develop new, purpose-built microscopes. These cutting-edge machines allow us to answer questions no one has been able to approach in the past.
A partly 3-D printed microscope with a fully automated stage that can be made from readily available components. Microscopi can be controlled from any touch screen device via a web browser.
A novel open-source approach for user-friendly fully programmable bespoke microscopy. This software allows users to integrate features such as hardware control, adaptive optics and structured illumination to their self-built imaging system.
We have developed a range of imaging and image analysis software to help users acquire and interpret a wide range of biological microscopy data. Using methods like machine learning and bioinformatics tools we can make large and complex data sets more manageable.