Tai Chaiamarit
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I joined the Davis lab in 2020 as a joint PhD/DPhil student in Biology/Biochemistry between The Scripps Research Institute (USA) and Oxford. I am interested in axonal transport regulation and how the process fails in neurological diseases. I am a member of Lincoln College and a Royal Thai scholar.
Current Project
I am interested in studying the complex regulation of RNA transport inside the long and thin nerves or axons of Drosophila, using genetics, biochemistry, and advanced microscopy approaches. Besides learning something new about RNA biology in the distal nerve ending, I am working towards developing a better correlative light-electron microscopy (CLEM) platform to follow RNA-protein-organelle interactions in space and time.
Previous Work
Before coming to Oxford, I spent the first half of my graduate study in the lab of Dr. Sandra Encalada at Scripps Research. There, I studied organelle trafficking processes that drive the formation of axonal mutant prion aggregates, we called ‘endoggresomes.’ In addition, I worked on elucidating the mechanisms that mutant prions disrupt mitochondrial function in mammalian axons.
Prior to my PhD, I graduated with B.S. in Biology (Neurobiology) from the University of Wisconsin-Madison (USA). I previously worked on dissecting metabolic pathways that drive biofilm development in a Gram-positive bacterium Bacillus subtilis
Publications
Chassefeyre R*, Chaiamarit T*, Verhelle A*, Novak SW, Andrade LR, Manor U, Encalada SE. Endosomal Sorting Drives the Formation of Mutant Prion Endoggresomes. bioRxiv (2020) *Co-authors
Nieto Torres JL, Shanahan SL, Chassefeyre R, Chaiamarit T, Zaretski S, Landeras-Bueno S, Encalada SE, Hansen M. LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes. Current Biology (Under Review).
Pisithkul T, Schroeder JW, Trujillo EA, Yeesin P, Stevenson DM, Chaiamarit T, Coon JJ, Wang JD, Amador-Noguez D. Metabolic Remodeling during Biofilm Development of Bacillus subtilis. mBio (2019)