Jeff Lee
About me
I am a Postdoctoral Scientist at the University of Glasgow. My research explores how RNA regulation ensures the healthy functioning of the nervous system, and how disruptions to this process contribute to neurodegenerative diseases, such as Amyotrophic Lateral Sclerosis (ALS). My work involves a combination of advanced imaging techniques, RNA biochemistry, next-generation sequencing, and bioinformatics.
Alongside my core research, I have a strong interest in technology development. I specialise in RNA in situ hybridisation techniques and led our lab's collaborative work on the single-molecule visualisation of SARS-CoV-2 genomes during the COVID-19 pandemic.
Career progression
2016 BSc Biochemistry - Imperial College London (Supervisor: Bernadette Byrne)
2017 MPhil Biological Sciences - University of Cambridge (Supervisor: Guy Brown)
2022 DPhil Biochemistry - University of Oxford (Supervisor: Ilan Davis)
Selected publications
Please see Google Scholar or ORCiD profiles for the full list of publications.
Lee, JY.*, Huang, N., Samuels, TJ., & Davis, I*. (2025). Imp/IGF2BP and Syp/SYNCRIP temporal RNA interactomes uncover combinatorial networks of regulators of Drosophila brain development. Science Advances. 11 (6), eadr6682, *Co-corresponding authors.
Lee, JY.*, Gala, DS.*, Kiourlappou, M., Olivares‐Abril, J., Joha, J., Titlow, JS., & ... (2024). Murine glial protrusion transcripts predict localized Drosophila glial mRNAs involved in plasticity. Journal of Cell Biology. 223 (10), *Co-first authors.
Titlow, JS.*, Kiourlappou, M.*, Palanca, A.*, Lee, JY.*, Gala, DS., Ennis, D., Yu, JJS., & ... (2023). Systematic analysis of YFP traps reveals common mRNA/protein discordance in neural tissues. Journal of Cell Biology. 222 (6), e202205129, *Co-first authors.
Lee, JY.*, Wing, PAC.*, Gala, DS., Noerenberg, M., Järvelin, AI., Titlow, J., & ... (2022). Absolute quantitation of individual SARS‐CoV‐2 RNA molecules provides a new paradigm for infection dynamics and variant differences. Elife. 11, e74153, *Co-first authors.
Wickenhagen, A., Sugrue, E., Lytras, S., Kuchi, S., Noerenberg, M., Turnbull, ML., … Lee, JY & … (2021). A prenylated dsRNA sensor protects against severe COVID‐19. Science. 374 (6567), eabj3624
Kamel, W., Noerenberg, M., Cerikan, B., Chen, H., Järvelin, AI., Kammoun, M., … Lee, JY & … (2021). Global analysis of protein‐RNA interactions in SARS‐CoV‐2‐infected cells reveals key regulators of infection. Molecular cell. 81 (13), 2851‐2867. E7
Puigdellívol, M., Milde, S., Vilalta, A., Cockram, TOJ., Allendorf, DH., Lee, JY., & ... (2021). The microglial P2Y6 receptor mediates neuronal loss and memory deficits in neurodegeneration. Cell Reports. 37 (13)
Contact
Email jeff.lee@glasgow.ac.uk
Address: Lab 253, Wolfson Link Building, University Avenue,
University of Glasgow, Glasgow, UK, G12 8QQ.