Jeff Lee

I joined the Davis lab in 2017 as a DPhil student working on the post-transcriptional regulation in neurogenesis. I am a member of St John's College and a Clarendon Scholar.

Current Project

I am interested in how post-transcriptional mechanisms govern neural stem cell proliferation and differentiation during brain development. Particularly, I focus on the cis and trans-acting factors acting through highly extended 3'UTR in transcript regulations. I am also working on our lab's Sars Cov2 and other virus research collaborations.

Previous Work

Before coming to Oxford I studied at the University of Cambridge (Downing College), completing an MPhil in Biological Science. I worked in Prof Guy Brown's lab exploring the role of a phagocytic receptor (P2Y6) and how neurons and synapses could be eaten alive by microglia.

Prior to my MPhil I completed a BSc in Biochemistry at the Imperial College London where I purified and characterised plant borate transporters for the final year project under Prof Bernadette Byrne's supervision.

Publications

2020

Samuels TJ, Arava Y, Järvelin AI, Robertson F, Lee JY, Yang L, Yang CP, Lee T, Ish-Horowicz D, Davis I. Neuronal upregulation of Prospero protein is driven by alternative mRNA polyadenylation and Syncrip-mediated mRNA stabilisation. Biol Open.

2017

Yi J-H, Brown C, Whitehead G, Piers T, Lee YS, Perez CM, Regan P, Whitcomb DJ, Cho K. Glucocorticoids activate a synapse weakening pathway culminating in tau phosphorylation in the hippocampus. Pharmacol Res.

Contact

Tel: 01865 613271